Multi-dose Vial 28- Day Expiration Calculator

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Solu-medrol Solu-medrol Generic Name & Formulations General Description

Methylprednisolone (as sodium succinate) 40mg (contains lactose), 125mg, 500mg, 1g; per vial; pwd for IV or IM inj; preservative-free; multi-dose vials 500mg, 1g, 2g; diluent contains benzyl alcohol.

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Pharmacological Class


Multi Dose Calendar Expiration Date :-Free Calendar Template
Multi Dose Calendar Expiration Date :-Free Calendar Template

How Supplied

Tabs 2mg—100; 4mg—100, 500; 8mg, 32mg—25; 16mg—50; Dosepak—21; Depo-Medrol multi-dose vial (20mg/mL)—1; (40mg/mL, 80mg/mL)—1, 25; Single-dose vial (40mg/mL, 80mg/mL)—1; Solu-Medrol single-dose vial (500mg, 1g)—1; (40mg, 125mg)—25; Multi-dose vial (500mg, 1g)—1; Vial with diluent (2g)—1

Multi Dose Vial  Day Expiration Calendar :-Free Calendar
Multi Dose Vial Day Expiration Calendar :-Free Calendar

Generic Availability

Tabs, dosepak (YES); Depo-medrol: 20mg/mL (NO); 40mg/mL, 80mg/mL (YES); Solu-medrol: 40mg, 125mg, 500mg, 1g (YES); 2g (NO)

Multi dose vial  day expiration calendar : Fill out & sign
Multi dose vial day expiration calendar : Fill out & sign

Solu-medrol Indications Indications

Steroid-responsive disorders where oral therapy not feasible.

Solu-medrol Dosage and Administration Adult

See full labeling. Individualize. Initially 10–40mg IV; subsequent doses IV or IM. For high-dose therapy: give 30mg/kg IV over 30mins; may repeat every 4–6hrs for 48hrs.


See full labeling. Individualize. Initially 0.11–1.6mg/kg/day in 3–4 divided doses IV or IM.

Solu-medrol Contraindications Contraindications

Systemic fungal infections. Live vaccines. Depo-Medrol, Solu-Medrol: also premature infants (benzyl alcohol content), intrathecal administration, idiopathic thrombocytopenic purpura (IM preparations). Allergy to cow’s milk or other dairy products (Solu-Medrol 40mg).

Solu-medrol Boxed Warnings

Not Applicable

Solu-medrol Warnings/Precautions Warnings/Precautions

Not for epidural use; serious neurologic events may occur. Cerebral malaria, optic neuritis: not recommended. Latent or active amebiasis. Strongyloides infestation. Ocular herpes simplex. Cirrhosis. Tuberculosis. If exposed to chickenpox or measles, consider prophylactic passive immune therapy. Ulcerative colitis if perforation pending. Peptic ulcer. Diverticulitis. Intestinal anastomoses. Myasthenia gravis. Systemic sclerosis. Recent MI. CHF. Hypertension. Renal insufficiency. Osteoporosis. Diabetes. Hypothyroidism. Kaposi’s sarcoma. Supplement with additional steroids in physiologic stress. May increase risk and mask signs of infection. May cause electrolyte imbalances, adrenocortical insufficiency, psychotic derangements. Alternate, intermittent, or single-daily doses at 8 AM minimize adrenal suppression. Monitor weight, growth, fluid and electrolyte balance. IV: drug-induced liver injury; discontinue if toxic hepatitis occurs. Intrasynovial: avoid previously infected or unstable joints. Solu-Medrol 40mg: consider allergy to cow’s milk if new or worsening allergic symptoms occur; use alternatives. Avoid abrupt cessation. Use lowest effective dose. Pregnancy (Cat.C). Nursing mothers: not recommended.

Solu-medrol Pharmacokinetics

See Literature

Solu-medrol Interactions Interactions

Potentiated by CYP3A4 inhibitors (eg, ketoconazole, macrolides), cyclosporine, estrogens. Antagonized by CYP3A4 inducers (eg, barbiturates, phenytoin, carbamazepine, rifampin), cholestyramine. May potentiate cyclosporine (seizure risk). May antagonize oral anticoagulants (monitor), isoniazid. Increased risk of arrhythmias with digitalis. May need to adjust dose of antidiabetic agents. Monitor for hypokalemia with potassium-depleting drugs (eg, amphotericin B, diuretics). Concomitant neuromuscular blocking agents; increased risk of myopathy. Withdraw anticholinesterase agents at least 24hrs before initiating corticosteroid therapy. Aminoglutethimide may lead to loss of corticosteroid-induced adrenal suppression. Increased GI effects with aspirin, other NSAIDs. Caution with aspirin in hypoprothrombinemia. May suppress reactions to skin tests.

Solu-medrol Adverse Reactions Adverse Reactions

HPA axis suppression, increased susceptibility to infection, glaucoma, cataracts, secondary infections, hypokalemia, hypocalcemia, hypernatremia, hypertension, CHF, psychic disorders, myopathy, osteoporosis, peptic ulcer, dermal atrophy, increased intracranial pressure, carbohydrate intolerance. Parenteral: atrophy, flare at site; intrasynovial: septic arthritis.

Solu-medrol Clinical Trials

See Literature

Solu-medrol Note

Not Applicable

Solu-medrol Patient Counseling

See Literature